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KMID : 0360419740100010031
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Korean Journal of Pharmacology
1974 Volume.10 No. 1 p.31 ~ p.40
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Potentiating Effect of Prostagliandin E₁ on the Action of Sympathomimetics in the Isolated Vas Deferns of Guinea-Pig
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Abstract
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1. The authors investigated the effects of PGE₁ on the action of sympathomimetics in the vas deferens of guinea-pig, comparing with those in the rat vas deferens, and also the action of PGE₁ on the motility of nerve-free smooth muscle of chick amnion.
2. In the isolated guinea-pig vas deferens, the actions of phenylephrine and norepinephrine were much potentiated by pretreatment with PGE₁. Futher, in the isolated hypogastric nerve-vas deferens preparation of guinea-pig, effects of phenylephrine, norepinephrine and tyramine on the contractile response of vas to the hypogastric nerve stimulation and to the transmural stimulation were also augumented especially in tension by PGE₁-pretreatment.
3. Tn the isolated hypogastric nerve-vas preparation of rat, both contractile responses to hypogastric nerve and transmural stimulation were slowly reduced by treatment with PGE₁ and the potentiated effect of phenylephrine or norepinephrine was not observed in spite of pretreatment with PGE₁.
4. The actions of phenylephrine and norepinephrine on the denervated vas deferens of guinea-pig were also enhanced by PGE₁ as it were in the intact vas deferens, but there was no significant effect by PGE₁ on the action of norepinephrine in the denervated rat vas deferens.
5. PGE₁ in low concentration (10^(-8)g/ml) did not affect the spontaneous motility of nerve-free smooth muscle of chick amnion (g~ll th day incubated chick), but in large concentration (5×10^(-8)g/ml) it caused irregular and slightly inhibitory movement. Pretreatment with PGE₁ on chick amnion did not exert any change on the action of phenylephrine applied. However, the stimulatory action of physostigmine on the chick amnion was a little antagonized by the low concentration of PGE₁.
6. It might be summarized that there is species difference between the actions of PGE₁ on the vas deferens of guinea-pig and that of rat, and the action of PGE₁ on the guinea-pig vas deferens might be mediated by the other mechanism rather than by direct action on the vas musculature.
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